%0 Journal Article
%T Vanishing tumors of thyroid: histological variations after fine needle aspiration
%A Ahmed Deniwar
%A Andrew Sholl
%A Emad Kandil
%A Fadi Murad
%A Hossam Eldin Mohamed
%A Parisha Bhatia
%A Rizwan Aslam
%J SCIE-indexed Journal
%D 2016
%X Fine needle aspiration (FNA) cytology is considered the gold standard in the diagnosis of thyroid nodules that may require surgical excision. The advent of FNA has led to a decreased number of unnecessary surgeries performed for benign thyroid tumors; however, malignant nodules can be missed in a minority of cases (1,2). The reported sensitivity of thyroid FNA results is 65¨C99% while its specificity is 72¨C100% (3-5). A standard protocol followed after detection of a thyroid nodule on palpation is to perform a thyroid ultrasound (US). According to the revised guidelines of the American Thyroid Association (ATA), thyroid US is being increasingly used for nodules >1 cm in size. Nodules presenting with US features suspicious of malignancy, such as presence of micro-calcification, hypo-echogenicity, ¡°taller-than-wide¡± shape and increased vascularity, are subsequently examined by FNA biopsy to detect the presence and type of cancer cells (6). However, 15¨C20% of the nodules are deemed indeterminate on cytological results (7). The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) uses three categories that fall in the ¡°grey zone¡± between benign and malignant cytology: follicular lesion of undetermined significance/atypia of undetermined significance (FLUS/AUS), suspicion for follicular neoplasm (FN)/H¨¹rthle cell neoplasm, and suspicious for malignancy, the sensitivity of which is variable according to different investigators (7-11). The definite diagnosis of these nodules is provided by histological examination following surgical excision of the tumor
%U http://gs.amegroups.com/article/view/9194/11007