%0 Journal Article
%T The role of Lp-PLA 2  and biochemistry parameters as potential biomarkers of coronary artery disease in Asian South-Indians: a case-control study
%A Asha Barooah
%A Carani Balaraman Sanjeevi
%A Janardhana Chelli
%A Jiten Jaipuria
%A Sai Giridhar Sairam
%A Sai Kiran Javvaji
%A Srikanth Sola
%A Vijayalakshmi Venkateshan
%J SCIE-indexed Journal
%D 2017
%X Coronary artery disease (CAD) is the leading cause of death and disability worldwide (1,2). Inflammation plays a key role in CAD and the various phases of atherosclerotic plaque development and rupture (3,4). Lipoprotein associated phospholipase A2 (Lp-PLA2) is a proinflammatory enzyme that is expressed in tissues that contain large numbers of macrophages. While in circulation, Lp-PLA2 [also known as platelet activating factor-acetylhydrolase (PAF-AH)] associates with diverse lipoproteins including high and low density lipoproteins (HDL and LDL) (3). Both Lp-PLA2 activity and mass (concentration) are associated with CAD as well as cerebrovascular outcomes (4). Several large studies including ARIC, WOSCOPS, MONICA, and Rotterdam have demonstrated that Lp-PLA2 is an independent predictor of CAD (5)
%U http://cdt.amegroups.com/article/view/16499/17923