%0 Journal Article %T Successful rebuilding after disaster, even in the heart, starts with infrastructure %A Douglas B. Sawyer %A Michael P. Robich %A Sergey Ryzhov %J SCIE-indexed Journal %D 2018 %R 10.21037/jtd.2018.10.95 %X Mammalian heart regeneration has been the subject of intense debate and investigation among cardiovascular scientists for more than a century (1). While it is now widely accepted that the mammalian heart does have the capacity for self-renewal, replacement of injured tissue with new cardiomyocytes happens at a very low rate in the adult heart, and is not sufficient for the recovery of cardiac function after massive loss of cells (2) %U http://jtd.amegroups.com/article/view/25148/html