%0 Journal Article
%T Post-treatment change in  Mycobacterium tuberculosis  antigen-stimulated tumor necrosis factor-alpha release in patients with active tuberculosis
%A Chang Ho Kim
%A Jae Yong Park
%A Jaehee Lee
%A Seung Ick Cha
%A Seung Soo Yoo
%A Shin Yup Lee
%J SCIE-indexed Journal
%D 2015
%R 10.3978/j.issn.2072-1439.2015.05.08
%X The central dogma of protective immunity to Mycobacterium tuberculosis (MTB) is the interplay between MTB-infected macrophages and T cells, which is mediated by numerous cytokines produced by both cell types (1). In particular, CD4+ T cells play a major role by producing interferon-gamma (IFN-¦Ã), which synergizes with tumor necrosis factor-alpha (TNF-¦Á) and potentiates macrophages that are capable of restricting the growth of MTB (1,2). Thus, the evaluation of cytokine expression elicited by the cellular responses to MTB-specific antigen (Ag) has been exploited as one way to detect TB infection. As such, the interferon-gamma release assay (IGRA) has led to further advances in the diagnosis of TB infection
%U http://jtd.amegroups.com/article/view/4400/html