%0 Journal Article
%T Upregulated GP73 expression and downregulated NLRP3 expression in liver cancer tissues correlate with patient¡¯s survival
%A Huayu Yang
%A Lejia Sun
%A Xianju Qin
%A Yilei Mao
%A Yixin Mao
%J SCIE-indexed Journal
%D 2018
%R 10.21037/20831
%X Liver cancer is the second leading cause of tumor-related deaths worldwide and has an incidence of around 850,000 new cases per year about half of them in China (1,2). Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. HCC occurs usually in people with cirrhosis caused by hepatitis B or hepatitis C infection, alcohol intake and ingestion of the fungal metabolite aflatoxin B1. The normal outcome is poor, because only 10¨C20% of HCC can be resected completely using surgery (3). If the tumor cannot be completely resected, the patients are usually died within 3 to 6 months (4). However, the poor prognosis could be improved due to the detection of early-stage tumors (5). Hepatectomy, transplantation or local ablation are effective therapies at early stage but only chemoembolization and sorafenib have shown survival benefits at developed stages (6). Therefore, it will be important to develop new techniques for diagnosis and prognostic prediction in order to get more curative treatment for patients with HCC
%U http://tcr.amegroups.com/article/view/20831/html