%0 Journal Article %T Characterization of genomic clones using circulating tumor DNA in patients with hepatocarcinoma %A Chen Fan %A Gang Wu %A Jun Xue %A Karsten Kristiansen %A Rui Meng %A Xiao-Ming Wei %A Yan Sun %A Yun Yang %A Zheng-Yu Cheng %J SCIE-indexed Journal %D 2018 %R 10.21037/20515 %X Cell-free tumor DNA (ctDNA), harboring tumor-specific mutations, is released by apoptotic and necrotic tumor cells and found in the cell-free fraction of blood (1). Plasma derived ctDNA has been recognized as a potential non-invasive surrogate for tumor tissue biopsies, also known as ¡°liquid biopsy¡± (2). Massively parallel sequencing (MPS) studies of ctDNA have revealed that ctDNA is a potential marker related to various forms of human cancers (3-5). It can be used as a potential marker to predict disease risk, patient outcomes or response to treatment %U http://tcr.amegroups.com/article/view/20515/html