%0 Journal Article %T Sparing chemotherapy with dual HER2 blockade in combination with endocrine therapy for advanced HER2 positive breast cancer %A Andr¨¦ Poisl Fay %A Gustavo Werutsky %A Tom¨¢s Reinert %J SCIE-indexed Journal %D 2018 %R 10.21037/21115 %X The ALTERNATIVE trial has shown progression-free survival (PFS) benefit with the addition of lapatinib (LAP) to trastuzumab (TRAS) and an aromatase inhibitor (AI) among postmenopausal patients with hormone receptor (HR), human epidermal growth factor receptor 2 (HER2)-positive, metastatic breast cancer (MBC). These findings were reported by Johnston et al. in the Journal of Clinical Oncology (1) %U http://tcr.amegroups.com/article/view/21115/html