%0 Journal Article %T Mechanisms of resistance to chemotherapy and radiotherapy in hepatocellular carcinoma %A Bin Guo %A Chuntao Wu %A Dianxing Liu %A Jiapei Guo %A Jinghua Wu %A Jun Shi %A Junmao Chen %A Leilei Li %A Xiaowei Zhang %J SCIE-indexed Journal %D 2018 %R 10.21037/21791 %X Hepatocellular carcinoma (HCC) is a common malignant tumor locating at hepatic or hepatobiliary cells and presents a high mortality rate. The incidence of HCC morbidity is approximately 850,000 new cases per year (1). Epidemiological statistics in recent years have shown that over 80% of HCC occurred in eastern Asia and southern Africa, where the morbidity exceeds 2¡ë. In developed countries, the average morbidity is 1¨C2¡ë in southern Europe, while it is less than 0.5¡ë in northern Europe, Oceania and America (2-4) %U http://tcr.amegroups.com/article/view/21791/html