%0 Journal Article
%T Potential predictive value of  JAK2  expression for Pan-cancer response to PD-1 blockade immunotherapy
%A De-Hua Wu
%A Jie Peng
%A Kun-Yuan Wang
%A Li Liu
%A Lu-Shan Xiao
%A Wen-Wen Li
%A Zhong-Yi Dong
%J SCIE-indexed Journal
%D 2018
%R 10.21037/21488
%X Immunotherapy represents a recent major breakthrough in cancer treatment. In particular, programmed cell death protein-1 (PD-1), programmed cell death ligand 1 (PD-L1), and PD-L2 pathways constitute key immune checkpoints. The PD-1 inhibitors nivolumab and pembrolizumab have induced durable control and shown a survival benefit in immunogenic tumors, such as non-small cell lung carcinoma, melanoma, renal cell carcinoma, and head and neck cancer (1)
%U http://tcr.amegroups.com/article/view/21488/html