%0 Journal Article
%T Hypertension and risk of cholangiocarcinoma: a systematic review and meta-analysis
%A Haitao Zhao
%A Hanchun Huang
%A Jianping Xiong
%A Jianzhen Lin
%A Jin Bian
%A Junyu Long
%A Tianyi Chi
%A Weiyu Xu
%A Xin Lu
%A Yi Bai
%A Yiyao Xu
%J SCIE-indexed Journal
%D 2018
%R 10.21037/21315
%X Cholangiocarcinoma (CCC), initially described by Durand Fardel in 1840, is a malignant cancer originated from the epithelium of bile duct (1,2). CCC represents the second most common primary hepatic carcinoma, accounting for 3% of all gastrointestinal malignancies as well as 10¨C25% of liver malignancies (3,4). Moreover, in recent decades, the incidence of CCC is still rising. Intriguingly, the epidemiology of intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC) are different, with an increasing incidence of the former, but a decreasing incidence of the latter in certain regions worldwide, including the UK and the USA (5). In the past 20 years, the incidence of ICC has been elevated by 165%, while that of ECC has been declined by 14% in the US (6). In addition, the prognosis of CCC is very poor. The relative survival rates of 1, 3 and 5 years have been reported to be 25%, 9.7% and 6.8%, respectively, almost any change in recent decades (7,8). And the cause of CCC is not yet fully understood, with only several confirmed risk factors of CCC, including gallstones, primary sclerosing cholangitis, parasitic infections as well as bile-duct cysts (9). Recently, additional indicators affecting CCC risks have been determined by multiple meta-analyses, including cirrhosis, alcohol consumption, smoking, and diabetes mellitus (10-14). In recent years, increasing attention has been paid to hypertension for its relationship with endometrial cancer and breast cancer (15,16). Moreover, the association between hypertension and CCC has been documented in case-control studies. However, its association is controversial. To this end, this systematic review with meta-analysis enrolling published observational researches was carried out to obtain a better understanding of the correlation of hypertension with the risk of CCC
%U http://tcr.amegroups.com/article/view/21315/html