%0 Journal Article %T Discrepancies between ALK protein disruption and occurrence of ALK gene rearrangement in Polish NSCLC patients %A Aleksandra Szcz£¿sna %A Anna Grenda %A Barbara Ku£¿nar-Kami¨½ska %A Bo£¿ena Jarosz %A Halina Batura-Gabryel %A Janusz Milanowski %A Juliusz Pankowski %A Justyna Szumi£¿o %A Kamila Wojas-Krawczyk %A Katarzyna Reszka %A Kinga Krukowska %A Krystyna Siemi£¿tkowska %A Maciej Bryl %A Marcin Nico£¿ %A Micha£¿ Palonka %A Pawe£¿ Krawczyk %A Rodryg Ramlau %A Tomasz Grodzki %A Tomasz Kucharczyk %J SCIE-indexed Journal %D 2018 %R 10.21037/jtd.2018.07.28 %X Lung cancer (LC) is the most common cause of death among men and women considering cancer mortality in the word. The main causes of LC are smoking and exposure to radon. LC is predominantly detected in an advanced stage with poor prognosis. On molecular level LC is heterogeneous, however some molecular patterns of this disease could be observed. In non-small cell lung cancer (NSCLC), the presence of EGFR, ALK, ROS1, BRAF, MET and HER2 abnormalities might qualify patients to molecularly targeted treatment (in routine practice or in clinical trials) %U http://jtd.amegroups.com/article/view/22793/html