%0 Journal Article
%T MicroRNA-374b inhibits the tumor growth and promotes apoptosis in non-small cell lung cancer tissue through the p38/ERK signaling pathway by targeting JAM-2
%A Lijuan Yu
%A Tao Wang
%A Yujun Wang
%J SCIE-indexed Journal
%D 2018
%R 10.21037/jtd.2018.09.93
%X Lung cancer is considered as the most lethal and prevalent cancer worldwide, clinically characterized by high malignancy, high mortality, and low 5-year survival rates (1). The number of lung cancer-related mortalities is more than 1.4 million annually, which is considered the primary form of cancer-related mortality worldwide (2). Non-small cell lung cancer (NSCLC) is closely associated with distant metastasis and is difficult to treat. Currently, surgical treatment, radiotherapy, and chemotherapy are widely used to treat NSCLC. However, the treatment methods for NSCLC have low efficiency and are unable to control tumor progression. Thus, basic studies on NSCLC are critical for its accurate prognosis, early detection, and effective treatment (3). As such, it is vital to understand the mechanism underlying the development of NSCLC and accordingly develop an effective and desirable treatment method
%U http://jtd.amegroups.com/article/view/24268/html