%0 Journal Article
%T Sonic hedgehog promotes endothelial differentiation of bone marrow mesenchymal stem cells via VEGF-D
%A Haoyue Huang
%A Jiacheng Sun
%A Junjie Yang
%A Qingyou Meng
%A Sheng Shi
%A Teng Ma
%A Xuan Liu
%A Yunsheng Yu
%A Zhenya Shen
%A Ziying Yang
%J SCIE-indexed Journal
%D 2018
%R 10.21037/jtd.2018.09.50
%X Bone marrow-derived mesenchymal stem cells (BMSCs) have been proven effective for therapeutic angiogenesis in in-vitro and in-vivo animal experiments and in clinical settings (1-3). The angiogenic properties of BMSCs can be attributed to direct differentiation into endothelial cells (ECs) and the paracrine effect as well (4). It has been reported that only a very small fraction of BMSCs could differentiate into ECs in vitro (3). There have been few studies demonstrating the concrete EC oriented differentiation of MSCs in vivo (5)
%U http://jtd.amegroups.com/article/view/24095/html