%0 Journal Article
%T The Wnt/¦Â-catenin pathway is activated by miR-1246 in liver cancer stem cells
%A Gregory S. Yochum
%A Melanie A. Eshelman
%J SCIE-indexed Journal
%D 2016
%R 10.21037/11194
%X The Wnt/¦Â-catenin signaling pathway drives stem cell proliferation and self-renewal (1). As the key transducer of the Wnt signal, the ¦Â-catenin transcriptional coactivator is tightly regulated (2). In the absence of Wnt, cytoplasmic ¦Â-catenin is found in a complex containing axis inhibition proteins 1 and 2 (AXIN1/2), adenomatous polyposis coli (APC), glycogen synthase kinase 3 beta (GSK3¦Â), and casein kinase 1 epsilon (CK1¦Å). Here, it is phosphorylated on its amino terminal residues, ubiquitinated by beta-transducin repeat containing protein, and targeted for proteasomal degradation. When Wnt ligand is present, ¦Â-catenin levels are stabilized and it translocates into the nucleus to activate target gene expression
%U http://tcr.amegroups.com/article/view/11194/html