%0 Journal Article
%T Normal tissue tolerance
%A Klaus-R¨¹diger Trott
%A Thomas Herrmann
%A Wolfgang D£¿rr
%J SCIE-indexed Journal
%D 2017
%R 10.21037/14602
%X Normal tissue radiation tolerance refers to the response of previously unirradiated tissues to a variety of very different exposure scenarios: total or large partial body exposure with ¡®high¡¯ doses in an ¡®acute¡¯ manner, e.g., in radiation accidents, or in a more ¡®chronic¡¯ way, e.g., through close and permanent contact with radioactive sources. A more localized ¡®high¡¯ dose, conformed to specific target structures, is achieved with modern radiotherapy techniques. In contrast, concentration of ¡®low¡¯ radiation doses is usually induced with most diagnostic procedures that involve ionizing radiation; however, the latter is also imminent in radiotherapy outside the high-dose structures. The present overview will not include the response of highly sensitive tissues (e.g., the eye lens, gonads, embryo/fetus). Also, the tolerance of normal tissues to radiation induction or promotion of tumours will not be covered. This present review rather focuses on the standard OAR in radiotherapy
%U http://tcr.amegroups.com/article/view/14602/html