%0 Journal Article
%T Development and validation of a polygenic hazard score for aggressive prostate cancer identification
%A Ashutosh K. Tewari
%A Kamlesh K. Yadav
%A Nihal E. Mohamed
%J SCIE-indexed Journal
%D 2019
%R 10.21037/25668
%X Prostate cancer (PCa) is a major health issue that affects over a million men globally every year (1). Although screening men for PCa using prostate specific antigen (PSA) estimates, over the past three decades, resulted in a significant improvement in quantity and quality of life, two major problems reduce the value of early screening using this method: (I) inaccuracy of test results (i.e., the receipt of false positive results), and (II) unnecessary aggressive treatment for low-risk PCa that could be managed via active surveillance or observation (2). These two major issues limited the global enthusiasm for early screening of PCa and influenced health policies supporting the utility of PCa screening tests in several countries. However, the need for a more efficient screening test to reduce disease burden and improve survival rates in men at risk of PCa because of genetic vulnerability or increasing age remained a challenge
%U http://tcr.amegroups.com/article/view/25668/html