%0 Journal Article
%T Postmastectomy radiation therapy in women with T1¨CT2 tumors and 1 to 3 positive lymph nodes: analysis of the breast international group 02-98 trial
%A Alba Fiorentino
%A Fabiana Gregucci
%A Laura Lozza
%A Maria Carmen De Santis
%J SCIE-indexed Journal
%D 2019
%R 10.21037/23691
%X In case of patients affected by breast cancer with more than 4 positive lymph nodes (LNs), postmastectomy radiation therapy (PMRT) has been widely adopted to reduce local relapse (1,2). Some controversies are still present regarding the use of PMRT for patients with 1¨C3 positive LNs. The updated meta-analysis of the Early Breast Cancer TrialistsĄŻ Collaborative Group (EBCTCG) published in 2014 regarding the effects of PMRT, performed additional analyses on 1.133 patients were affected by breast cancer with 1¨C3 positive LNs receiving axillary dissection and chemotherapy (3). The latter meta-analysis showed that the 10-year rate of locoregional failure was 21.0% and 4.3% for patients who received radiation therapy or not, respectively (P=0.001). The 10-year rate for any recurrence (locoregional or distant) was 45.5% and 33.8% without PMRT and with irradiation (P=0.001), and the respective 20-year rates of breast cancer mortality were 49.4% and 41.5% (P=0.01; relative risk, 0.78), respectively. The trials included in the EBCTCG meta-analysis were conducted in the 1970s and 1980s and chemotherapy used, was cyclophosphamide, methotrexate, and fluorouracil (CMF); or methotrexate plus fluorouracil; or single-agent cyclophosphamide or melphalan (Data Supplement Table 1) (3)
%U http://tcr.amegroups.com/article/view/23691/html