%0 Journal Article
%T Infiltrating regulatory T cells promote invasiveness of liver cancer cells via inducing epithelial-mesenchymal transition
%A Ai-Hua Huang
%A Bo Hu
%A Hong-Bo Wang
%A Lin-Bo Wang
%A Mei Jin
%A Ya-Bo Gao
%A Yi-Hong Wang
%A Zhi-Feng Wu
%A Zhi-Nong Jiang
%J SCIE-indexed Journal
%D 2019
%R 10.21037/32488
%X Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide, with recently escalating incidence and generally dismal outcomes (1,2). By far, surgical resection is still considered as the first option for HCC cure (3). However, postoperative survival remains unsatisfactory because of high recurrence and metastasis rates due to the high invasiveness potential of HCC cells (4-6). Therefore, a better understanding of HCC cell spread may provide novel insights into HCC management in the future. The transforming growth factor-¦Â1 (TGF¦Â1)-induced TGF¦Â signaling pathway has been reported to play a vital role in HCC progression and spread (7). Active TGF¦Â1 could trigger epithelial¨Cmesenchymal transition (EMT) in a Smad2/3-dependent manner, greatly promoting the invasiveness of tumor cells (8-10). Previous studies reported that regulatory T (Treg) cells were a critical resource of TGF¦Â1, and Treg-derived TGF¦Â1 could also promote tumor invasion (11,12). However, whether infiltrating Treg was an important origin of TGF¦Â1 in HCC, and its role in promoting HCC progression, remained elusive
%U http://tcr.amegroups.com/article/view/32488/html