%0 Journal Article
%T The construction and analysis of the aberrant lncRNA-miRNA-mRNA network in non-small cell lung cancer
%A Chengyuan Fang
%A Dayong Zheng
%A Hang Yin
%A Hao Jiang
%A Hao Liang
%A Jianqun Ma
%A Jinfeng Zhang
%A Jinhong Zhu
%A Luquan Zhang
%A Xiaodong Ling
%A Xiaoyuan Wang
%A Yanzhong Xin
%A Yingnan Yang
%J SCIE-indexed Journal
%D 2019
%R 10.21037/jtd.2019.05.69
%X Lung cancer is one of the most common cancer worldwide with the highest morbidity and mortality (1). Eighty to eighty-five percent of lung cancer is non-small cell lung cancer (NSCLC) (2). Though there is a great progress in surgery, chemotherapy and radiation therapy, the 5-year survival rate of NSCLC was still 15% (3). Hence, it is significantly important to have a deeper understanding of the molecular mechanism underlying NSCLC tumorigenesis and seek new therapeutic strategies for NSCLC. Moreover, the regional or distant metastasis will lead to high percent of mortality (4). Therefore, to better study the disease and find the new targets to cure has become extremely importantly. Long noncoding RNAs (lncRNAs) is a type of non-coding RNAs (ncRNAs) with 200 nucleotides to 100 kb in length (5). LncRNAs are with the function of regulating the target gene expression in the process of transcriptional and post-transcriptional but no protein-coding function (6). The research showed the manifestations of lncRNAs in tumors and normal tissues was different. Some lncRNAs played important roles in cancer progression and may be biomarkers in diagnosis, treatment and conditions of prognosis for its stronger tissue specificity (7). However, the clear mechanism of lncRNA in cancer was still not clear. In 2011, the theory of Competing endogenous RNA (ceRNA) hypothesis which is proposed by Sardina et al. was appealing (8). The main theory was some lncRNAs could have an effect of sponge on miRNAs which weak the impact of miRNAs on mRNAs. Additionally, there are more and more research showed the network of lncRNA, miRNA and mRNA is important in the pathogenesis and progression of cancers (9,10). For example, Zhang investigated the lncRNA analysed and built a lncRNA-miRNA-mRNA network in hepatocellular carcinoma (11). Besides, a ceRNA network of esophageal cancer was constructed (12). In renal cell cancer, a ceRNA network was constructed likewise (13). Nevertheless, the study of large-scale samples in NSCLC is uncommon. And the nexuses between prognosis and lncRNAs are undetermined. Therefore, building ceRNA network is very important for prognosis prediction, therapeutic decision and improving the overall survival (OS) for NSCLC sufferers
%U http://jtd.amegroups.com/article/view/29105/html