%0 Journal Article
%T Identification of potential microRNAs and their targets in promoting gefitinib resistance by integrative network analysis
%A Fushuang Zheng
%A Hongyan Zhang
%A Jibin Lu
%J SCIE-indexed Journal
%D 2019
%R 10.21037/jtd.2019.11.25
%X Lung cancer is one of the most frequent and fatal neoplasms. It is also the leading cause of cancer mortality in all parts of the world (1), with around 80¨C85% of lung cancers being non-small cell lung cancer (NSCLC). Despite being the most prevalent type of lung cancer, NSCLC remains a global challenge because of its high morbidity and mortality (2). Recently, molecular targeted therapy has dramatically arrived as a milestone clinical improvement for patients with precise genomic variations, especially for those patients with NSCLC-harboring epidermal growth factor receptor (EGFR)-sensitive mutations (3,4). EGFR-TKIs have been developed to resist epithelial-derived solid tumors for advanced NSCLC
%U http://jtd.amegroups.com/article/view/34057/html