%0 Journal Article
%T Expression of centrosomal protein 55 in glioma tissue and the influence on glioma cell functions
%A Tianyu Lu
%A Wei Jin
%A Weibang Liang
%A Weitao Chen
%A Wu Xu
%A Yifan Xu
%J SCIE-indexed Journal
%D 2019
%R 10.21037/26953
%X Glioma originates from glial cells of the human nervous system, as a primary brain tumor with the highest incidence rate in humans to date (1). In China, the morbidity rate of glioma is about 10¨C20/100,000, and its incidence rate accounts for about 1¨C3% of those of systemic malignant tumors and approximately 46% of those of intracranial tumors (2). According to epidemiological studies, the median survival time of low-grade (WHO grade II) gliomas is 6¨C8 years, and those of high-grade (WHO grades III and IV) gliomas are only 3 years and 1 year respectively (3). At present, glioma is mainly treated through surgical resection plus postoperative radiotherapy or chemotherapy. Many new therapies for glioma have been developed, including postoperative combination chemotherapy with bevacizumab and lomustine (4), as well as postoperative stereotaxic radiological technique and high-dose radiotherapy for elderly patients with glioblastoma (5). However, these therapies can only prolong the survival of patients instead of targeting gliomas. Therefore, basic research on glioma is of great significance
%U http://tcr.amegroups.com/article/view/26953/html