%0 Journal Article
%T CircNT5E/miR-422a: a new circRNA-based ceRNA network in glioblastoma
%A Deborah Morena
%A Francesca Picca
%A Riccardo Taulli
%J SCIE-indexed Journal
%D 2019
%R 10.21037/25448
%X The vast majority of human transcriptome is composed of non-coding RNAs (ncRNAs) that contribute to genetic and epigenetic regulation through complex interactions with proteins and nucleic acids. Circular RNAs (circRNAs) are a conserved class of ncRNAs, generated from a non-canonical back splicing process, that catalyzes a covalent bond between the 5' and 3' ends of a single-stranded RNA molecule (1). The absence of free ends makes circular RNAs extremely stable and resistant to degradation. Many circRNAs have a tissue-specific expression and are particularly abundant in mammalian brain (2). Moreover, multiple evidences show that circRNAs are critical in cancer pathogenesis exhibiting both oncogenic and tumor suppressive properties (3). However, despite their high expression level, the biological functions of circRNAs are still poorly understood. Interestingly, a critical function assigned to circRNAs is the ability to act as ˇ°competing endogenous RNAsˇ± (ceRNAs), subtracting microRNAs from their natural mRNA targets. As a result, circRNAs regulate gene expression establishing a dynamic crosstalk with numerous transcripts (4)
%U http://tcr.amegroups.com/article/view/25448/html