%0 Journal Article %T NIBIT-MESO-1: limitations and clinical perspectives in MPM treatment testing an immune checkpoint blockade combination in a single-arm study %A Paolo Bironzo %A Riccardo Taulli %J SCIE-indexed Journal %D 2018 %R 10.21037/jtd.2018.09.135 %X Malignant pleural mesothelioma (MPM), which is linked to asbestos exposure and is a rare, lethal disease of the serosal membrane in the chest, has an incidence which continues to increase worldwide (1,2). MPM is histologically classified into three major subtypes: epithelioid, biphasic (or mixed) and sarcomatoid. Notwithstanding these well-defined MPM histological subtypes, there are tremendous differences in clinical outcomes including long-term survival in patients whose tumor histology is indistinguishable from conventional, highly aggressive MPM %U http://jtd.amegroups.com/article/view/24508/html