%0 Journal Article
%T ERBB4 promotes the progression of inflammatory breast cancer through regulating PDGFRA
%A Boni Ding
%A Ni Gong
%A Runliu Wu
%A Wei Wu
%J SCIE-indexed Journal
%D 2020
%R 10.21037/tcr-19-2132
%X Breast cancer is the most common and harmful malignant tumor clinically, accounting for nearly 25% of all cancer cases in females. It is also the second cause leading to cancer-related morbidity among women worldwide (1). As a unique form of breast cancer with a strongly aggressive and poor prognosis, inflammatory breast cancer (IBC) predominantly invade and attack the breast subcutaneous lymphatic vessels (2,3). It is critical to realize that IBC is distinctly different from other breast cancers in clinically and pathologically. Rather than presenting as a clinically apparent mass, IBC tumor cells diffuse rapidly and pervade within the breast, contributing to ˇ°inflammatoryˇ± changes such as breast skin redness and swelling, and distant metastasis in the short term (4,5). The incidence of IBC increased at a rate of 1.23% to 4.35% yearly (2). Lacking of effective therapeutic regimens makes IBC a global challenge. Therefore, further study in the molecular mechanism of tumor invasion and metastasis in IBC is urgently needed
%U http://tcr.amegroups.com/article/view/38642/html