%0 Journal Article
%T Dual-Responsive Molecular Probe for Tumor Targeted Imaging and Photodynamic Therapy
%A Dapeng Ni
%A Guanhui Gao
%A Guanjun Deng
%A Lihua Zhou
%A Lintao Cai
%A Mingbin Zheng
%A Ping Gong
%A Sanpeng Li
%A Tao Jiang
%A Wenjun Li
%A Xiaoqing Meng
%A Yalin Lv
%A Yayun Wu
%A Yueting Yang
%A li Zhang
%J Theranostics
%D 2017
%I Ivyspring International Publisher
%R 10.7150/thno.18437
%X The precision oncology significantly relies on the development of multifunctional agents to integrate tumor targeting, imaging and therapeutics. In this study, a first small-molecule theranostic probe, RhoSSCy is constructed by conjugating 5กไ-carboxyrhodamines (Rho) and heptamethine cyanine IR765 (Cy) using a reducible disulfide linker and pH tunable amino-group to realize thiols/pH dual sensing. In vitro experiments verify that RhoSSCy is highly sensitive for quantitative analysis and imaging intracellular pH gradient and biothiols. Furthermore, RhoSSCy shows superb tumor targeted dual-modal imaging via near-infrared fluorescence (NIRF) and photoacoustic (PA). Importantly, RhoSSCy also induces strongly reactive oxygen species for tumor photodynamic therapy (PDT) with robust antitumor activity both in vitro and in vivo. Such versatile small-molecule theranostic probe may be promising for tumor targeted imaging and precision therapy.
%K Small-molecule theranostic probe
%K Dual-stimuli sensing
%K NIRF/PA imaging
%K tumor targeting
%K Photodynamic therapy.
%U http://www.thno.org/v07p1781.htm