%0 Journal Article
%T Noninvasive Assessment of Elimination and Retention using CT-FMT and Kinetic Whole-body Modeling
%A Andrea Melle
%A Andrij Pich
%A Fabian Kiessling
%A Felix Gremse
%A Lia Appold
%A Nataliia Beztsinna
%A Simin Zuo
%A Susanne Koletnik
%A Twan Lammers
%A Wa'el Al Rawashdeh
%A Yoanna Tsvetkova
%J Theranostics
%D 2017
%I Ivyspring International Publisher
%R 10.7150/thno.17263
%X Fluorescence-mediated tomography (FMT) is a quantitative three-dimensional imaging technique for preclinical research applications. The combination with micro-computed tomography (¦ĚCT) enables improved reconstruction and analysis. The aim of this study is to assess the potential of ¦ĚCT-FMT and kinetic modeling to determine elimination and retention of typical model drugs and drug delivery systems.
%K Fluorescence-mediated tomography
%K kinetic modeling
%K micro-computed tomography
%K elimination routes
%K retention sites
%K OsteoSense
%K microbubbles
%K nanogels
%K indocyanine green.
%U http://www.thno.org/v07p1499.htm