%0 Journal Article
%T Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis
%A Fan Yang
%A Fengjiao Wang
%A Jianqun Ma
%A Jinfeng Ning
%A Junfeng Wang
%A Kaibin Zhu
%A Shidong Xu
%A Wei Liu
%A Xiangyuan Jin
%A Xiaoguang Li
%A Xiuyun Wang
%A Yaoguo Lang
%J International Journal of Biological Sciences
%D 2018
%R 10.7150/ijbs.23542
%X Pyroptosis is a form of caspase-1-dependent programmed cell death with anti-tumor properties, but the underlying molecular mechanisms are not fully understood. The results of our study showed that the antihyperlipidemic drug simvastatin induced pyroptosis in non-small cell lung cancer (NSCLC) cell lines and a xenograft mouse model. Inhibition of pyroptosis attenuated the effects of simvastatin on tumor cell viability and migration. These data suggest that simvastatin may induce pyroptosis, thereby potentially serving as a novel therapeutic agent for NSCLC.
%K Simvastatin
%K NSCLC
%K pyroptosis
%K caspase-1
%K cancer therapy
%U http://www.ijbs.com/v14p0406.htm