%0 Journal Article
%T Effects of boron on the proliferation, apoptosis and immune function of splenic lymphocytes through ER¦Á and ER¦Â
%A Erhui Jin
%A Man Ren
%A Qianqian Hu
%A Shenghe Li
%A Ting Liu
%A Yaqiong Pei
%A Youfang Gu
%J Food and Agricultural Immunology
%D 2019
%R https://doi.org/10.1080/09540105.2019.1626809
%X ABSTRACT This experiment aimed to investigate the role of ER¦Á and ER¦Â in boron's effect on splenic lymphocyte of rat. After inhibition of ER¦Á and ER¦Â using MPP and PHTPP, the effects of 0.4£¿mmol/L boron on the splenic CD4+/CD8+ T-cell ratio, lymphocyte proliferation rate, IFN-¦Ã concentration and PCNA protein expression disappeared. Furthermore, after inhibiting ER¦Â with PHTPP alone, the decreasing effects of 40£¿mmol/L boron on the splenic CD8+ T-cell proportion, lymphocyte proliferation rate, the concentrations of IgG and cytokines, as well as the expression of Bcl-2 also disappeared. However, when ER¦Á was inhibited by MPP alone, the effect of 40£¿mmol/L boron on splenic lymphocyte was unchanged. The results suggest that ER¦Á mainly mediate the effects of low-dose boron (0.4£¿mmol/L) on splenic T-cell subsets, lymphocyte proliferation and apoptosis, and immune function, while ER¦Â may mediate the effects of both low-dose and high-dose boron (40£¿mmol/L) on splenic lymphocytes
%U https://www.tandfonline.com/doi/full/10.1080/09540105.2019.1626809