%0 Journal Article
%T Preparation of polyacrylamide/polylactic acid co-assembled core/shell nanofibers as designed beads for dapsone in vitro efficient delivery
%A Abbas Pardakhty
%A Arezou Amanatfard
%A Batool Tahamipour
%A Mehdi Ranjbar
%A Payam Khazaeli
%J Artificial Cells, Nanomedicine, and Biotechnology
%D 2019
%R https://doi.org/10.1080/21691401.2019.1577881
%X Abstract The main aim of this study is to synthesize and prepare polyacrylamide (PAM)/polylactic acid (PLA) co-assembled core/shell nanofibers in order to investigate an effective dapsone-loaded capability and dapsone-release in the aqueous medium. Dapsone (4,4-diamino-diphenyl sulfone) has high permeability and low solubility in water. In vitro release testing indicates that maximum incorporation of the dapsone nanoemulsions into core/shell nanofibrous structures were 77.71 after 400£¿min. Products were characterized with X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Fourier Transform Infrared Spectroscopy (FT-IR), Thermo-Gravimetric Analysis (TGA), Dynamic light scattering (DLS) analysis, Contact Angle Measurement (CAM) and nitrogen adsorption [i.e. Brunauer-Emmett-Teller (BET) Surface Area Analysis] techniques. The porosimetric measurements of the nanofibers structures showed that high porosity diameter, adsorption cross-section area, pore volumes and dead volume were obtained as 0.162£¿nm2, 0.1005£¿cm3g£¿1 and 15.693£¿cm3, respectively. TGA curve of the core/shell nanofibrous structures shows thermal stability between 240£¿¡ãC and 260£¿¡ãC. Graphical Abstrac
%U https://www.tandfonline.com/doi/full/10.1080/21691401.2019.1577881