%0 Journal Article
%T Paeonol prevents IL-1¦Â-induced inflammatory response and degradation of type II collagen in human primary chondrocytes
%A Qianjun Wang
%A Xiaomei Xu
%A Yanmin Li
%A Zhentao Zhang
%A Zhiqiang Kang
%J Artificial Cells, Nanomedicine, and Biotechnology
%D 2019
%R https://doi.org/10.1080/21691401.2019.1613418
%X Abstract Osteoarthritis (OA) is a common joint disease for which a safe and reliable treatment has yet to be developed. Here, we demonstrated the potential benefit of treatment with paeonol, a derivative of Paeonia suffruticosa, in the treatment and prevention of OA. Chondrogenic cell line ATDC5 cells were cultured with IL-1¦Â and the effects of paeonol were assessed through qRT-PCR, western blot analysis, MTT, ELISA, and NF-¦ÊB luciferase reporter gene assay. Our findings demonstrate a novel ability of paeonol to inhibit numerous factors of OA, including expressions of IL-6, TNF-¦Á, NOX2, PTGS2, NUCB2/nesfatin-1, ICAM-1, VCAM-1, MMP-3/13, degradation of type II collagen, and NF-¦ÊB activation through the rescue of I¦ÊB¦Á. Additionally, we assessed the effects of paeonol on cell viability to confirm its safety. These findings implicate a valuable potential role of paeonol in the treatment and prevention of OA
%U https://www.tandfonline.com/doi/full/10.1080/21691401.2019.1613418