%0 Journal Article
%T Membrane Repair Mechanisms against Permeabilization by Pore-Forming Toxins
%A Asier Etxaniz
%A C¨¦sar Mart¨ªn
%A David Gonz¨¢lez-Bull¨®n
%A Helena Ostolaza
%J Archive of "Toxins".
%D 2018
%R 10.3390/toxins10060234
%X Permeabilization of the plasma membrane represents an important threat for any cell, since it compromises its viability by disrupting cell homeostasis. Numerous pathogenic bacteria produce pore-forming toxins that break plasma membrane integrity and cause cell death by colloid-osmotic lysis. Eukaryotic cells, in turn, have developed different ways to cope with the effects of such membrane piercing. Here, we provide a short overview of the general mechanisms currently proposed for plasma membrane repair, focusing more specifically on the cellular responses to membrane permeabilization by pore-forming toxins and presenting new data on the effects and cellular responses to the permeabilization by an RTX (repeats in toxin) toxin, the adenylate cyclase toxin-hemolysin secreted by the whooping cough bacterium Bordetella pertussis, which we have studied in the laboratory
%K membrane permeabilization
%K membrane repair
%K pore-forming toxins
%K RTX toxins
%K adenylate cyclase toxin
%K Bordetella pertussis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024578/