%0 Journal Article
%T The sandfly Lutzomyia longipalpis LL5 embryonic cell line has active Toll and Imd pathways and shows immune responses to bacteria, yeast and Leishmania
%A Andr¨¦ N¨®brega Pitaluga
%A Bruno Tinoco-Nunes
%A Christiane Marques
%A Daisy Aline Azevedo-Brito
%A Erich Loza Telleria
%A Monique da Silva-Neves
%A Yara Maria Traub-Csek£¿
%J Archive of "Parasites & Vectors".
%D 2016
%R 10.1186/s13071-016-1507-4
%X Lutzomyia longipalpis is the main vector of visceral leishmaniasis in Latin America. Sandfly immune responses are poorly understood. In previous work we showed that these vector insects respond to bacterial infections by modulating a defensin gene expression and activate the Imd pathway in response to Leishmania infection. Aspects of innate immune pathways in insects (including mosquito vectors of human diseases) have been revealed by studying insect cell lines, and we have previously demonstrated antiviral responses in the L. longipalpis embryonic cell line LL5
%K Lutzomyia longipalpis
%K Embryonic cell line LL5
%K Innate immune response
%K Toll pathway
%K Imd pathway
%K Antimicrobial peptides
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839078/