%0 Journal Article
%T Thermal hyperalgesic effects induced by intracerebroventricular injection of interleukin-1βin rats
%A Ji Guangchen
%A Ma Fei
%A Wu Gencheng
%A Zhang Yuqiu
%J 生理学报
%D 2002
%X The present study was to investigate the effects of intracerebroventricular (i. c. v.) injection ofinterleukin-1β (IL-1β) on thermal nociception in SD rats. The rats were divided into control and drug-administered groups. The animals of control group were given vehicle solution via i. c. v. injection. The animals of drug-administered groups were given IL-1β at different doses (5, 50 and 500 pg/kg b. w.) via i. c. v. injection. IL-1 receptor antagonist (IL-1 ra, 50 ng/kg) was injected 20 min before injection of IL-1β or vehicle solution. The nociceptive threshold, which was represented as paw withdrawal latency (PWL), to a noxious thermal stimulation was measured using an analgesiameter. I. c. v. injection of IL-1β dose-dependently shortened the PWL. At the dose of 500 pg/kg, the shortening of the PWL occurred at 20 min, reaching a peak within 40 min, lasted 100 min after injection, then gradually returned to the baseline level. Pretreatment with IL-1 ra completely blocked the effects of IL-1β-induced shortening in PWL. The results obtained suggest that IL-1β may induce hyperalgesia in rats through binding to IL-1 receptors in the brain.
%K 白介素-1β
%K 热痛敏作用
%K 脑
%U http://www.actaps.com.cn/article.php?id=6129