%0 Journal Article
%T Hsa-mir-144-3p expression is increased in umbilical cord serum of infants with atopic dermatitis
%A Akifumi Eguchi
%A Chisato Mori
%A Eishika Dissanayake
%A Fumiya Yamaide
%A Hiroko Suzuki
%A Hiroyuki Kojima
%A Masaru Taniguchi
%A Naoki Shimojo
%A Satomi Hasegawa
%A Shingo Ochiai
%A Taiji Nakano
%A Yoichi Kohno
%A Yuzaburo Inoue
%J Journal of Allergy and Clinical Immunology
%D 2019
%R 10.1016/j.jaci.2018.09.024
%X Atopic dermatitis (AD) is a common chronic inflammatory disease of childhood. Up to
60% of cases appear during the first year of life, and most resolve during the first
few years.1 The skin of patients with AD is characterized by several abnormalities
in barrier function, including altered lipid composition, decreased number of tight
junctions, altered protease activity, and altered antimicrobial activity.2 The dual
exposure to allergen hypothesis suggests that tolerance to antigens occurs in the
neonate through high-dose oral exposure and allergen sensitization occurs through
low-dose cutaneous exposure.
%U https://www.jacionline.org/article/S0091-6749(18)31428-3/abstract