%0 Journal Article
%T Use of Biomarker Based on Human Basophil Syk Expression to Predict the Clinical Efficacy of Omalizumab Treatment in Allergic Asthmatics
%A Donald MacGlashan
%A Sarbjit Singh Saini
%J Journal of Allergy and Clinical Immunology
%D 2017
%R 10.1016/j.jaci.2016.12.548
%X Treatment with omalizumab results in the increased sensitivity of basophils to IgE-mediated
stimulation, likely due to an increase in syk expression in basophils. Studies in
patients with peanut allergy suggested that the increased sensitivity works in opposition
to the therapeutic benefits of reduced free IgE. This study examined whether a priori
knowledge of syk expression or maximum IgE-mediated histamine release, which is related
to syk expression, would provide a predictor of the efficacy of omalizumab in patients
with allergic asthma.
%U https://www.jacionline.org/article/S0091-6749(16)32066-8/abstract