%0 Journal Article
%T Mast Cells Suppress IL-33 Induced Innate-Type Allergic Airway Inflammation By Promoting Regulatory T Cell Expansion
%A Cezmi A. Akdis
%A Hideaki Morita
%A Hirohisa Saito
%A Kenji Matsumoto
%A Susumu Nakae
%J Journal of Allergy and Clinical Immunology
%D 2017
%R 10.1016/j.jaci.2016.12.542
%X IL-33 is a member of the IL-1 cytokine family and is considered to be crucial for
the induction of type 2 immune responses. Since mast cells are known to secrete inflammatory
mediators in response to IL-33 in vitro even in the absence of immunoglobulin E, mast
cells are considered to be a major effector cells in allergic inflammation. However,
the roles of mast cells in IL-33-induced innate-type allergic airway inflammation
in vivo remain unclear. The aim of this study is to clarify the roles of mast cells
in IL-33-induced innate-type allergic airway inflammation.
%U https://www.jacionline.org/article/S0091-6749(16)32060-7/abstract