%0 Journal Article
%T Effect of KIT Inhibition by Imatinib on Airway Mast Cells in Patients with Severe Refractory Asthma (KIA)
%A Allison Crosby-Thompson
%A Denise Garofalo
%A Elliot Israel
%A Emily DiMango
%A Howard Katz
%A Jennifer L. Trevor
%A Jing Cui
%A Joshua A. Boyce
%A Juying Lai
%A Kartik Shenoy
%A Katherine N. Cahill
%A Mario Castro
%A Michael E. Wechsler
%A Nizar N. Jarjour
%A Serpil C. Erzurum
%A Shamsah Kazani
%A Tanya M. Laidlaw
%A Vernon M. Chinchilli
%J Journal of Allergy and Clinical Immunology
%D 2017
%R 10.1016/j.jaci.2016.12.553
%X Mast cells (MCs) persist in severe asthmatic airways despite corticosteroid treatment.
Stem cell factor and its receptor, KIT, are central to MC homeostasis. We evaluated
the effect of imatinib, a KIT inhibitor, on airway mast cells in patients with severe
asthma.
%U https://www.jacionline.org/article/S0091-6749(16)32071-1/abstract