%0 Journal Article
%T Transforming Growth Factor-Beta 1 (TGF-Beta 1) Gene Polymorphisms are Associated with Atopic Asthma and Helminth Infections in an Admixed Population
%A Camila Alexandrina Figueiredo
%A Candelaria Vergara
%A Cassandra Foster
%A Joseph Potee
%A Kathleen C. Barnes
%A Lain Pontes-de-Carvalho
%A Laura Rodrigues
%A Mauricio Lima Barreto
%A Monica Campbell
%A Neuza Maria Alcantara-Neves
%A Nicholas M. Rafaels
%A Rasika A. Mathias
%A Ryan Santos Costa
%A ¨¢lvaro Cruz
%J Journal of Allergy and Clinical Immunology
%D 2017
%R 10.1016/j.jaci.2016.12.377
%X The prevalence of allergies has been growing rapidly throughout the world, being inversely
associated with reduction of exposure to pathogen. Helminth infections are characterized
by mobilization of regulatory T cells producing TGF-¦Â1 that allow for parasite survival
and may contribute to protection against allergies. However, allergies are complex
diseases determined by both, environmental and genetic factors. We hypothesized that
polymorphisms in TGFB1 are associated with helminth infections and allergies.
%U https://www.jacionline.org/article/S0091-6749(16)31895-4/abstract