%0 Journal Article
%T Th2-Related Chemokine Receptors Do Not Always Reflect Th2 Cells Under Physiological Conditions
%A Hirokazu Murakami
%A Satoru Watanabe
%A Yoshiyuki Yamada
%J Journal of Allergy and Clinical Immunology
%D 2017
%R 10.1016/j.jaci.2016.12.371
%X Disruption of the balance between T-helper (Th)-1 and Th2 cells leads to various immune
abnormalities. Chemokine receptors such as CCR3, CCR4, CCR7, and CCR8 and the PGD2
receptor, CRTH2, are associated with Th2. However, the distribution of these receptors
on Th2 cells under physiological conditions is only partly reported as ˇ°control.ˇ±
Indeed, the frequencies of these receptors, which indicate Th2 cell populations in
those ˇ°controls,ˇ± vary with each study. This study was aimed at determining whether
Th2-related chemokine receptors could be surface surrogate markers for cytoplasmic
Th2 cytokine staining, even under physiological conditions.
%U https://www.jacionline.org/article/S0091-6749(16)31889-9/abstract