%0 Journal Article
%T Dust Mite-Induced Allergic Pulmonary Inflammation Is Differentially Regulated By Il33-/- and Il1rl1-/- Dendritic Cells
%A Eri Yoshimoto
%A Li Li
%A Min Jung Lee
%A Yoshihide Kanaoka
%A null
%J Journal of Allergy and Clinical Immunology
%D 2016
%R 10.1016/j.jaci.2015.12.246
%X Many studies have reported genetic associations between IL-33, its receptor IL1RL1
(ST2), and asthma. However, the cellular sources of IL-33 and the mechanisms by which
it promotes Th2 pulmonary inflammation are poorly understood. We and others have shown
that IL-33 is elicited by house dust mite (HDM) activation of the C-type lectin receptor
Dectin-2 in dendritic cells (DCs). Therefore, we sought to determine the contribution
of IL-33 and IL1RL1 to DC-mediated allergic pulmonary inflammation.
%U https://www.jacionline.org/article/S0091-6749(15)01988-0/abstract