%0 Journal Article
%T Cardiolipin Provides a Platform for Caspase-1 Activation and NLRP3 Inflammasome Assembly
%A Eric Elliott
%A Shankar S. Iyer
%A Suzanne L. Cassel
%A null
%J Journal of Allergy and Clinical Immunology
%D 2016
%R 10.1016/j.jaci.2015.12.244
%X The NLRP3 inflammasome promotes innate immunity through Caspase-1 activation and IL-1¦Â
and IL-18 maturation. Two-step NLRP3 activation requires an initial NF¦ÊB-activating
priming stimulus and secondary agonist which induces cation flux and mitochondrial
stress. However, the dynamics of inflammasome assembly and extent of mitochondrial
disruption required for NLRP3 activation remain uncertain. NLRP3 interacts with mitochondrial
cardiolipin, and we hypothesized cardiolipin could activate NLRP3 in vitro.
%U https://www.jacionline.org/article/S0091-6749(15)01986-7/abstract