%0 Journal Article
%T The parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity in experimental asthma
%A Akane Tanaka
%A Cliff Taggart
%A Jenna Shiels
%A Jennifer Simpson
%A John P. Dalton
%A Joyce To
%A Maria B. Sukkar
%A Maria Lund
%A Natalia Tiberti
%A Sheila Donnelly
%A Simon Phipps
%A Sinead Weldon
%A Valery Combes
%A Venkata Sita Rama Raju Allam
%J Journal of Allergy and Clinical Immunology
%D 2018
%R 10.1016/j.jaci.2018.01.050
%X During infection of their mammalian hosts, parasitic worms (helminths) secrete molecules
that modulate the host immune response toward a regulatory phenotype. This ensures
the long-term survival of the parasite within its host and also prevents£¿excessive
tissue damage mediated by inflammatory immune responses. We reported the identification
of a novel immunomodulatory 68-mer peptide secreted by the animal and human parasite
Fasciola hepatica, termed F hepatica helminth defense molecule 1 (FhHDM-1).
%U https://www.jacionline.org/article/S0091-6749(18)30330-0/abstract