%0 Journal Article
%T Associations Between Asthma Severity and Responsiveness to Th2- and Th17-derived Cytokines in Pediatric Asthmatics
%A Andrew Warren Lindsley
%A Christopher G. McKnight
%A Emily Kim
%A Ian Paul Lewkowich
%A Jaclyn W. McAlees
%A Jocelyn M. Biagini Myers
%A Melinda Butsch Kovacic
%A Richard Thomas Strait
%A Sara L. Hall
%A Theresa Baker
%A Xue Zhang
%J Journal of Allergy and Clinical Immunology
%D 2018
%R 10.1016/j.jaci.2017.12.244
%X Mild and moderate allergic asthma are characterized by airway eosinophilia, airway
hyperresponsiveness and a maladaptive Th2 response to aeroallergens, which is typically
well controlled with steroids. Severe steroid refractory asthma is often associated
with neutrophilic inflammation, elevated Th17 cell numbers and IL-17A. A mouse model
of allergen-driven severe asthma supports an association between Th17 responses and
severe disease, and demonstrate that severely asthmatic animals have increased production
of Th17 cytokines and responsiveness to IL-17A.
%U https://www.jacionline.org/article/S0091-6749(17)32144-9/abstract