%0 Journal Article
%T Reply
%A Alexander J. Schuyler
%A Cosby A. Stone
%A Elizabeth J. Phillips
%A John M. Fahrenholz
%A Jonathan A. Hemler
%A R. Stokes Peebles
%A Scott P. Commins
%J Journal of Allergy and Clinical Immunology
%D 2018
%R 10.1016/j.jaci.2017.08.048
%X Retterer et£¿al1 note that their patient reacted to zoster vaccine, and then was primarily
found to be sensitized to gelatin 3£¿years later, without alpha-gal¨Cspecific IgE. In
their assessment, the best explanation is that the gelatin-specific IgE is more likely
the culprit in the previous reaction to zoster vaccine than alpha-gal¨Cspecific IgE.
They suggest for this specific patient that tick bites inoculate other antigens such
as gelatin that could potentially sensitize the patient.2 Alternatively, we suggest
that before the availability of alpha-gal¨Cspecific IgE testing the patient may have
had positive specific IgE to alpha-gal (and gelatin and beef), but the circulating
alpha-gal¨Cspecific IgE antibody concentrations diminished over time, as is frequently
observed in our clinics when patients successfully avoid further tick bites and red
meat.
%U https://www.jacionline.org/article/S0091-6749(17)31891-2/abstract