%0 Journal Article
%T Farm dust reduces viral load in human bronchial epithelial cells by increasing barrier function and antiviral responses
%A Christoph M¨¹ller
%A Dennis K. Ninaber
%A Erika von Mutius
%A Franz Bracher
%A Gimano D. Amatngalim
%A Hermelijn H. Smits
%A Katrien Eger
%A Luci£¿n E.P.M. van der Vlugt
%A Maria C. Zarcone
%A Pieter S. Hiemstra
%J Journal of Allergy and Clinical Immunology
%D 2018
%R 10.1016/j.jaci.2018.01.025
%X Early-life respiratory infections caused by rhinoviruses (RVs) and/or respiratory
syncytial virus can lead to recurrent wheezing and constitute one of the most dominant
risk factors for the development of asthma.1 Multiple studies show that growing up
on farms is associated with protection against allergies, rhinitis, and asthma.2 Similarly,
farm children also suffer less from virus-induced wheezing in the first years of life.2
An increased susceptibility to RVs and respiratory syncytial virus could be related
to a weakened epithelial barrier function facilitating viral penetration and/or reduced
antiviral responses, such as, a lower IFN production.
%U https://www.jacionline.org/article/S0091-6749(18)30210-0/abstract