%0 Journal Article
%T Transcriptome analysis of T cells in chromosome 22q11.2 deletion syndrome
%A Daniel P. Heruth
%A Hongying Dai
%A Marcia A. Chan
%A Min Xiong
%A Nicole M. Gigliotti
%A Nikita Raje
%A Shui Qing Ye
%J Journal of Allergy and Clinical Immunology
%D 2018
%R 10.1016/j.jaci.2017.12.075
%X T cell lymphopenia in chromosome 22q11.2 deletion syndrome (22qDS) is related to varying
degrees of thymic hypoplasia. No phenotype correlation with genotype or deletion size
is known for lymphopenia. We hypothesized that T-cell transcriptome is different in
22qDS from healthy children and this difference is associated with lymphocyte counts
and function leading to clinically diverse phenotypes.
%U https://www.jacionline.org/article/S0091-6749(17)31975-9/abstract