%0 Journal Article
%T Study of Specific IgE Recognition of New Potential Synthetic Antigenic Determinants for ¦Á-Amino-Cephalosporins
%A Alba Rodriguez-Nogales
%A Angela Martin-Serrano Ortiz
%A Cristobalina Mayorga
%A Esther Barrionuevo
%A Ezequiel Perez-Inestrosa
%A Maria Isabel MontaŁżez
%A Maria Jose Torres Ja¨¦n
%J Journal of Allergy and Clinical Immunology
%D 2018
%R 10.1016/j.jaci.2017.12.112
%X Cephalosporins are, after penicillins, the most important betalactam inductor of immediate
allergic reactions. Due to difficulties for studying the structure of cephalosporin-protein
conjugates, the antigenic determinants of cephalosporins are still unknown. This fact
has hampered the existence of in vitro tests with enough sensitivity to detect allergy
to cephalosporins. The objective was to synthesize pyrazinone-like derivatives of
two aminocephalosporins as potential antigenic determinants and evaluate their specific
IgE recognition.
%U https://www.jacionline.org/article/S0091-6749(17)32012-2/abstract