%0 Journal Article
%T Ultra-Rapid Reporting of GENomic Targets (URGENTseq): Clinical Next-Generation Sequencing Results within 48 Hours of Sample Collection
%A Bedia A. Barkoh
%A C. Cameron Yin
%A Chi Young Ok
%A Courtney D. DiNardo
%A David Hatfield
%A Haitham Khogeer
%A John Galbincea
%A Keyur P. Patel
%A Kristen Floyd
%A L. Jeffrey Medeiros
%A Mark J. Routbort
%A Rajyalakshmi Luthra
%A Rashmi Kanagal-Shamanna
%A Roberto Ruiz-Cordero
%A Sanam Loghavi
%A Sergio Rodriguez
%A Wei Chen
%A Zhuang Zuo
%J The Journal of Molecular Diagnostics
%D 2019
%R 10.1016/j.jmoldx.2018.08.002
%X Next-generation sequencing (NGS)-based mutation panels profile multiple genes simultaneously,
allowing the reporting of numerous genes while saving labor and resources. However,
one drawback of using NGS is that the turnaround time is often longer than conventional
single gene tests. This delay can be problematic if molecular results are required
to guide therapy in patients with clinically aggressive diseases, such as acute myeloid
leukemia. To overcome this limitation, we developed a novel custom platform designated
as Ultra-rapid Reporting of GENomic Targets (URGENTseq), an integrated solution that
includes workflow optimization and an innovative custom bioinformatics pipeline to
provide targeted NGS results on fresh peripheral blood and bone marrow samples within
an actionable time period.
%U https://jmd.amjpathol.org/article/S1525-1578(18)30080-1/fulltext