%0 Journal Article
%T Comprehensive Genomic Profiling of Malignant Effusions in Patients with Metastatic Lung Adenocarcinoma
%A Chieh-Yu Lin
%A Christian A. Kunder
%A Christina S. Kong
%A Gerald J. Berry
%A Henning Stehr
%A James L. Zehnder
%A Soo-Ryum Yang
%A Steven R. Long
%J The Journal of Molecular Diagnostics
%D 2018
%R 10.1016/j.jmoldx.2017.10.007
%X Cytology samples are increasingly used for comprehensive molecular testing. Although
fine-needle aspirates are adequate substrates for high-throughput sequencing, the
suitability of malignant body fluids remains largely unexplored. We investigated the
adequacy and utility of performing targeted next-generation sequencing (NGS) on malignant
effusions from patients with metastatic lung adenocarcinoma. Thirty-two effusion samples
submitted for hybrid capture¨Cbased NGS using a clinically validated solid tumor genotyping
panel were examined.
%U https://jmd.amjpathol.org/article/S1525-1578(17)30348-3/fulltext