%0 Journal Article
%T Evaluation of a Hepatitis C Virus Core Antigen Assay in Plasma and Dried Blood Spot Samples
%A Angelica Soker
%A Behzad Hajarizadeh
%A Beth Catlett
%A Camelia Quek
%A Danica Martinez
%A Fran£¿ois M.J. Lamoury
%A Gavin Cloherty
%A Gregory J. Dore
%A Janaki Amin
%A Jason Grebely
%A Philip Cunningham
%A Philippa Marks
%A Tanya L. Applegate
%J The Journal of Molecular Diagnostics
%D 2018
%R 10.1016/j.jmoldx.2018.05.010
%X Simplified, affordable tools to diagnose active hepatitis C virus (HCV) infection
are needed to scale up treatment. This study evaluated the analytical performance
of HCV core antigen (HCVcAg) detection in samples of plasma and dried venous blood
spots (DBSs). Paired plasma and DBS samples were prepared from remnant diagnostic
samples, and plasma HCV RNA and HCVcAg were quantified. Sensitivity and specificity
for HCVcAg (>3 fmol/L) at two HCV RNA thresholds (¡İ15 and ¡İ3000 IU/mL) were calculated.
%U https://jmd.amjpathol.org/article/S1525-1578(17)30296-9/fulltext